Found 11 hits for monomerid = 50088908 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase ABL
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of PDGF-receptor kinase |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |
PDGFR-beta/Platelet-derived growth factor receptor alpha
(Mus musculus (mouse)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Tested in vitro for inhibition of non-receptor tyrosine kinase v-Abl |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Tested in vitro for inhibition of KDR-receptor tyrosine kinase |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Tested in vitro for inhibition of serine/threonine kinase Cdc2 |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Tested for inhibition of protein tyrosine kinase c-Src phosphorylation in intact cells |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |
Calmodulin/Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of c-Src kinase (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0308-3 BindingDB Entry DOI: 10.7270/Q2BZ68ZH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase CSK
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Tested for inhibition of protein tyrosine kinase Csk phosphorylation in intact cells |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Tested for inhibition of protein tyrosine kinase c-Src phosphorylation |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of PDGF-receptor kinase |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 50.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena
Curated by ChEMBL
| Assay Description Inhibition of c-Src |
Eur J Med Chem 44: 990-1000 (2009)
Article DOI: 10.1016/j.ejmech.2008.07.002 BindingDB Entry DOI: 10.7270/Q2ZC8434 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50088908
(5-(3-Methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyr...)Show InChI InChI=1S/C19H16N4O/c1-24-15-9-5-6-13(10-15)16-11-23(14-7-3-2-4-8-14)19-17(16)18(20)21-12-22-19/h2-12H,1H3,(H2,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Tested for inhibition of EGF-receptor tyrosine kinase in intact cells |
Bioorg Med Chem Lett 10: 945-9 (2000)
BindingDB Entry DOI: 10.7270/Q2R78DG4 |
More data for this Ligand-Target Pair | |