BDBM50089036 CHEMBL278881::Naphthalene-1-sulfonic acid {4-[2-(4-amino-quinazolin-2-ylamino)-ethyl]-cyclohexylmethyl}-amide

SMILES: Nc1nc(NCC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12

InChI Key: InChIKey=BZFSXCDMICUCTC-MXVIHJGJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50089036   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuropeptide Y receptor type 5 ( NPY Y5) (Homo sapiens (Human))	BDBM50089036 (CHEMBL278881 | Naphthalene-1-sulfonic acid {4-[2-(...) Show SMILES Nc1nc(NCC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12 |wU:7.6,wD:10.10,(3.44,-3.9,;3.45,-5.44,;4.79,-6.21,;4.81,-7.77,;6.14,-8.54,;7.47,-7.77,;8.56,-8.87,;9.89,-8.1,;9.89,-6.56,;11.23,-5.79,;12.56,-6.56,;13.91,-5.79,;15.22,-6.58,;16.55,-7.35,;16.54,-5.81,;16.54,-8.89,;18.08,-7.35,;18.43,-5.86,;19.9,-5.4,;21.03,-6.44,;20.7,-7.94,;21.82,-8.98,;21.49,-10.48,;20,-10.94,;18.88,-9.89,;19.23,-8.4,;12.55,-8.1,;11.22,-8.87,;3.46,-8.55,;2.12,-7.77,;.77,-8.56,;-.56,-7.78,;-.56,-6.23,;.77,-5.46,;2.12,-6.23,)| Show InChI InChI=1S/C27H31N5O2S/c28-26-23-9-3-4-10-24(23)31-27(32-26)29-17-16-19-12-14-20(15-13-19)18-30-35(33,34)25-11-5-7-21-6-1-2-8-22(21)25/h1-11,19-20,30H,12-18H2,(H3,28,29,31,32)/t19-,20-	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Antagonistic activity against neuropeptide Y receptor type 5 subtype stably expressed in LM(tk-)cells				Bioorg Med Chem Lett 10: 1175-9 (2000) BindingDB Entry DOI: 10.7270/Q2KH0MJP
					More data for this Ligand-Target Pair