BDBM50089585 2,6-Diamino-5-[2-(4,5-difluoro-2-nitro-phenylamino)-ethyl]-3H-pyrimidin-4-one::CHEMBL440950

SMILES: Nc1nc(N)c(CCNc2cc(F)c(F)cc2[N+]([O-])=O)c(=O)[nH]1

InChI Key: InChIKey=OQFZBIBWLZFXAQ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50089585   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycinamide ribonucleotide formyltransferase (GARFTase) (Homo sapiens (Human))	BDBM50089585 (2,6-Diamino-5-[2-(4,5-difluoro-2-nitro-phenylamino...) Show SMILES Nc1nc(N)c(CCNc2cc(F)c(F)cc2[N+]([O-])=O)c(=O)[nH]1 Show InChI InChI=1S/C12H12F2N6O3/c13-6-3-8(9(20(22)23)4-7(6)14)17-2-1-5-10(15)18-12(16)19-11(5)21/h3-4,17H,1-2H2,(H5,15,16,18,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 3 min at 250 uM				Bioorg Med Chem Lett 10: 1471-5 (2000) BindingDB Entry DOI: 10.7270/Q2GM86HD
					More data for this Ligand-Target Pair