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BDBM50090433 2-(5-Chloro-thiophen-2-yl)-4-(3-methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino)-pyrimidine-5-carboxylic acid ethyl ester::CHEMBL43259::ethyl 2-(5-chlorothiophen-2-yl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylate

SMILES: CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccc(Cl)s1

InChI Key: InChIKey=CRDXILZNMTVNLW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50090433   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene c-JUN/protein c-fos


(Homo sapiens (Human))
BDBM50090433
PNG
(2-(5-Chloro-thiophen-2-yl)-4-(3-methyl-2,5-dioxo-2...)
Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccc(Cl)s1 |t:16|
Show InChI InChI=1S/C16H13ClN4O4S/c1-3-25-16(24)9-7-18-14(10-4-5-11(17)26-10)19-13(9)20-21-12(22)6-8(2)15(21)23/h4-7H,3H2,1-2H3,(H,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 300n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells


Bioorg Med Chem Lett 10: 1645-8 (2000)


BindingDB Entry DOI: 10.7270/Q2F190XH
More data for this
Ligand-Target Pair