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BDBM50090435 3-Methyl-1-[5-(3-methyl-isoxazol-5-yl)-2-thiophen-2-yl-pyrimidin-4-ylamino]-pyrrole-2,5-dione::3-methyl-1-(5-(3-methylisoxazol-5-yl)-2-(thiophen-2-yl)pyrimidin-4-ylamino)-1H-pyrrole-2,5-dione::CHEMBL45261

SMILES: CC1=CC(=O)N(Nc2nc(ncc2-c2cc(C)no2)-c2cccs2)C1=O

InChI Key: InChIKey=HJAKTQAHKIJTKU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50090435   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene c-JUN/protein c-fos


(Homo sapiens (Human))
BDBM50090435
PNG
(3-Methyl-1-[5-(3-methyl-isoxazol-5-yl)-2-thiophen-...)
Show SMILES CC1=CC(=O)N(Nc2nc(ncc2-c2cc(C)no2)-c2cccs2)C1=O |t:1|
Show InChI InChI=1S/C17H13N5O3S/c1-9-6-14(23)22(17(9)24)20-15-11(12-7-10(2)21-25-12)8-18-16(19-15)13-4-3-5-26-13/h3-8H,1-2H3,(H,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 300n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells


Bioorg Med Chem Lett 10: 1645-8 (2000)


BindingDB Entry DOI: 10.7270/Q2F190XH
More data for this
Ligand-Target Pair