BDBM50090444 4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino)-2-phenyl-pyrimidine-5-carboxylic acid ethyl ester::CHEMBL42952::ethyl 4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-phenylpyrimidine-5-carboxylate
SMILES: CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccccc1
InChI Key: InChIKey=BMEOHHZTHGXSLS-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene c-JUN/protein c-fos (Homo sapiens (Human)) | BDBM50090444 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Signal Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells | Bioorg Med Chem Lett 10: 1645-8 (2000) BindingDB Entry DOI: 10.7270/Q2F190XH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50090444 (4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay | J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT | |||||||||||
More data for this Ligand-Target Pair |