BDBM50090642 (2Z,6E)-7,11-dimethyl-3-(2-methylpropyl)dodeca-2,6,10-trien-1-yl (phosphonatooxy)phosphonate::3-substituted farnesyl diphosphate analogue

SMILES: [#6]-[#6](-[#6])-[#6]\[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])=[#6]/[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O

InChI Key: InChIKey=AQRXJJFSRWORMJ-ZCCSIIRNSA-K

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50090642   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50090642 ((2Z,6E)-7,11-dimethyl-3-(2-methylpropyl)dodeca-2,6...) Show SMILES [#6]-[#6](-[#6])-[#6]\[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])=[#6]/[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C18H34O7P2/c1-15(2)8-6-9-17(5)10-7-11-18(14-16(3)4)12-13-24-27(22,23)25-26(19,20)21/h8,10,12,16H,6-7,9,11,13-14H2,1-5H3,(H,22,23)(H2,19,20,21)/p-3/b17-10+,18-12-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus				Bioorg Med Chem Lett 10: 1763-6 (2000) BindingDB Entry DOI: 10.7270/Q2BZ66KR
					More data for this Ligand-Target Pair