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BDBM50090676 (+-)-2-(p-(2-thenoyl)phenyl)propionic acid::2-(4-(2-Thenoyl)phenyl)propionsaeure::2-[4-(thiophen-2-ylcarbonyl)phenyl]propanoic acid::4-(2-Thenoyl)hydratropsaeure::CHEMBL956::SUPROFEN::alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid::p-2-thenoylhydratropic acid

SMILES: CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1

InChI Key: InChIKey=MDKGKXOCJGEUJW-UHFFFAOYSA-N

Data: 5 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50090676   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50090676
PNG
((+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-...)
Show SMILES CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Show InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
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1.10E+3n/an/an/an/an/an/an/an/a



St. Bartholomew's and the Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50090676
PNG
((+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-...)
Show SMILES CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Show InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
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3.70E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Mechanism based inhibition of human cytochrome P450 2C9


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM50090676
PNG
((+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-...)
Show SMILES CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Show InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
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PubMed
8.30E+3n/an/an/an/an/an/an/an/a



St. Bartholomew's and the Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM50090676
PNG
((+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-...)
Show SMILES CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Show InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
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PubMed
8.70E+3n/an/an/an/an/an/an/an/a



St. Bartholomew's and the Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50090676
PNG
((+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-...)
Show SMILES CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Show InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
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4.50E+4n/an/an/an/an/an/an/an/a



Washington State University

Curated by ChEMBL


Assay Description
Binding affinity measured on human cytochrome P450 2C9 (CYP2C9) enzyme


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM50090676
PNG
((+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-...)
Show SMILES CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Show InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
PDB
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Article
PubMed
n/an/a 2.75E+3n/an/an/an/an/an/a



Université de Lille 2

Curated by ChEMBL


Assay Description
Inhibition of COX2 in human whole blood


Bioorg Med Chem Lett 18: 4655-7 (2008)

More data for this
Ligand-Target Pair
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50090676
PNG
((+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-...)
Show SMILES CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Show InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
PDB

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antibodypedia
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CHEMBL
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KEGG
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PC sid
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Article
PubMed
n/an/a 560n/an/an/an/an/an/a



Université de Lille 2

Curated by ChEMBL


Assay Description
Inhibition of COX1 in human whole blood


Bioorg Med Chem Lett 18: 4655-7 (2008)

More data for this
Ligand-Target Pair