BDBM50091386 1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-ethanone::CHEMBL114129::CHEMBL128851

SMILES: CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1

InChI Key: InChIKey=FDJSGXRROVCWFT-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50091386   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50091386 (1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-ethano...) Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C14H16N2O2/c1-11(17)12-4-6-14(7-5-12)18-8-2-3-13-9-15-10-16-13/h4-7,9-10H,2-3,8H2,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Histamine H3 receptor antagonist activity in an assay with K+ evoked depolarization-induced release of [3H]-histamine from rat synaptosomes.				J Med Chem 43: 3335-43 (2000) BindingDB Entry DOI: 10.7270/Q2RR1XGV
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50091386 (1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-ethano...) Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C14H16N2O2/c1-11(17)12-4-6-14(7-5-12)18-8-2-3-13-9-15-10-16-13/h4-7,9-10H,2-3,8H2,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamine				J Med Chem 43: 3987-94 (2000) BindingDB Entry DOI: 10.7270/Q2833SRN
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50091386 (1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-ethano...) Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C14H16N2O2/c1-11(17)12-4-6-14(7-5-12)18-8-2-3-13-9-15-10-16-13/h4-7,9-10H,2-3,8H2,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of [125I]-iodoproxyfan from rat histamine H3 receptor expressed in CHO-K1 cells				Bioorg Med Chem Lett 11: 951-4 (2001) BindingDB Entry DOI: 10.7270/Q28P5ZRB
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50091386 (1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-ethano...) Show SMILES CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C14H16N2O2/c1-11(17)12-4-6-14(7-5-12)18-8-2-3-13-9-15-10-16-13/h4-7,9-10H,2-3,8H2,1H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	87	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of [125I]-iodoproxyfan binding to human histamine H3 receptor of CHO-K1 cells				Bioorg Med Chem Lett 11: 951-4 (2001) BindingDB Entry DOI: 10.7270/Q28P5ZRB
					More data for this Ligand-Target Pair