new BindingDB logo
myBDB logout

BDBM50092087 CHEMBL3580682

SMILES: CN(Cc1ccccc1)c1ccc2ncc(-c3ccc(cc3)C#N)n2n1

InChI Key: InChIKey=AJDJDSOIQFUPTC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50092087   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM50092087
PNG
(CHEMBL3580682)
Show SMILES CN(Cc1ccccc1)c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C21H17N5/c1-25(15-17-5-3-2-4-6-17)21-12-11-20-23-14-19(26(20)24-21)18-9-7-16(13-22)8-10-18/h2-12,14H,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...


ACS Med Chem Lett 6: 562-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00050
BindingDB Entry DOI: 10.7270/Q2TM7CW4
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50092087
PNG
(CHEMBL3580682)
Show SMILES CN(Cc1ccccc1)c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C21H17N5/c1-25(15-17-5-3-2-4-6-17)21-12-11-20-23-14-19(26(20)24-21)18-9-7-16(13-22)8-10-18/h2-12,14H,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...


ACS Med Chem Lett 6: 562-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00050
BindingDB Entry DOI: 10.7270/Q2TM7CW4
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50092087
PNG
(CHEMBL3580682)
Show SMILES CN(Cc1ccccc1)c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C21H17N5/c1-25(15-17-5-3-2-4-6-17)21-12-11-20-23-14-19(26(20)24-21)18-9-7-16(13-22)8-10-18/h2-12,14H,15H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 520n/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...


ACS Med Chem Lett 6: 562-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00050
BindingDB Entry DOI: 10.7270/Q2TM7CW4
More data for this
Ligand-Target Pair