BDBM50092232 2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol::CHEMBL419082

SMILES: Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1O

InChI Key: InChIKey=XBTDIGWGOZVBHQ-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50092232   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50092232 (2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...) Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1O Show InChI InChI=1S/C23H22N4O2/c24-22-21-18(13-27(23(21)26-14-25-22)19-7-4-8-20(19)28)15-9-11-17(12-10-15)29-16-5-2-1-3-6-16/h1-3,5-6,9-14,19-20,28H,4,7-8H2,(H2,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase catalytic domain at 1 mM ATP				Bioorg Med Chem Lett 10: 2167-70 (2001) BindingDB Entry DOI: 10.7270/Q2J38RTH
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50092232 (2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...) Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1O Show InChI InChI=1S/C23H22N4O2/c24-22-21-18(13-27(23(21)26-14-25-22)19-7-4-8-20(19)28)15-9-11-17(12-10-15)29-16-5-2-1-3-6-16/h1-3,5-6,9-14,19-20,28H,4,7-8H2,(H2,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibition of tie-2 at 5 uM ATP				Bioorg Med Chem Lett 10: 2167-70 (2001) BindingDB Entry DOI: 10.7270/Q2J38RTH
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50092232 (2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...) Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1O Show InChI InChI=1S/C23H22N4O2/c24-22-21-18(13-27(23(21)26-14-25-22)19-7-4-8-20(19)28)15-9-11-17(12-10-15)29-16-5-2-1-3-6-16/h1-3,5-6,9-14,19-20,28H,4,7-8H2,(H2,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibition of src at 5 mM ATP				Bioorg Med Chem Lett 10: 2167-70 (2001) BindingDB Entry DOI: 10.7270/Q2J38RTH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50092232 (2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...) Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1O Show InChI InChI=1S/C23H22N4O2/c24-22-21-18(13-27(23(21)26-14-25-22)19-7-4-8-20(19)28)15-9-11-17(12-10-15)29-16-5-2-1-3-6-16/h1-3,5-6,9-14,19-20,28H,4,7-8H2,(H2,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase at 5 uM ATP				Bioorg Med Chem Lett 10: 2167-70 (2001) BindingDB Entry DOI: 10.7270/Q2J38RTH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50092232 (2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...) Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1O Show InChI InChI=1S/C23H22N4O2/c24-22-21-18(13-27(23(21)26-14-25-22)19-7-4-8-20(19)28)15-9-11-17(12-10-15)29-16-5-2-1-3-6-16/h1-3,5-6,9-14,19-20,28H,4,7-8H2,(H2,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase catalytic domain at 1 mM ATP				Bioorg Med Chem Lett 10: 2167-70 (2001) BindingDB Entry DOI: 10.7270/Q2J38RTH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50092232 (2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...) Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1O Show InChI InChI=1S/C23H22N4O2/c24-22-21-18(13-27(23(21)26-14-25-22)19-7-4-8-20(19)28)15-9-11-17(12-10-15)29-16-5-2-1-3-6-16/h1-3,5-6,9-14,19-20,28H,4,7-8H2,(H2,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	<8	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase catalytic domain at 5 uM ATP				Bioorg Med Chem Lett 10: 2167-70 (2001) BindingDB Entry DOI: 10.7270/Q2J38RTH
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50092232 (2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...) Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1O Show InChI InChI=1S/C23H22N4O2/c24-22-21-18(13-27(23(21)26-14-25-22)19-7-4-8-20(19)28)15-9-11-17(12-10-15)29-16-5-2-1-3-6-16/h1-3,5-6,9-14,19-20,28H,4,7-8H2,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibition of Vascular endothelial growth factor receptor 2 at 5 uM ATP				Bioorg Med Chem Lett 10: 2167-70 (2001) BindingDB Entry DOI: 10.7270/Q2J38RTH
					More data for this Ligand-Target Pair