BDBM50092236 CHEMBL71541::{2-[4-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenoxy]-phenyl}-methanol

SMILES: CC(C)n1cc(-c2ccc(Oc3ccccc3CO)cc2)c2c(N)ncnc12

InChI Key: InChIKey=QTJNWMQSUXNJOF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50092236   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50092236 (CHEMBL71541 | {2-[4-(4-Amino-7-isopropyl-7H-pyrrol...) Show SMILES CC(C)n1cc(-c2ccc(Oc3ccccc3CO)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H22N4O2/c1-14(2)26-11-18(20-21(23)24-13-25-22(20)26)15-7-9-17(10-8-15)28-19-6-4-3-5-16(19)12-27/h3-11,13-14,27H,12H2,1-2H3,(H2,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibitory activity against tie-2 at a concentration of 5 microM ATP.				Bioorg Med Chem Lett 10: 2171-4 (2001) BindingDB Entry DOI: 10.7270/Q2DB813K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50092236 (CHEMBL71541 | {2-[4-(4-Amino-7-isopropyl-7H-pyrrol...) Show SMILES CC(C)n1cc(-c2ccc(Oc3ccccc3CO)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H22N4O2/c1-14(2)26-11-18(20-21(23)24-13-25-22(20)26)15-7-9-17(10-8-15)28-19-6-4-3-5-16(19)12-27/h3-11,13-14,27H,12H2,1-2H3,(H2,23,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase (catalytic domain)				Bioorg Med Chem Lett 10: 2171-4 (2001) BindingDB Entry DOI: 10.7270/Q2DB813K
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50092236 (CHEMBL71541 | {2-[4-(4-Amino-7-isopropyl-7H-pyrrol...) Show SMILES CC(C)n1cc(-c2ccc(Oc3ccccc3CO)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H22N4O2/c1-14(2)26-11-18(20-21(23)24-13-25-22(20)26)15-7-9-17(10-8-15)28-19-6-4-3-5-16(19)12-27/h3-11,13-14,27H,12H2,1-2H3,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 microM ATP.				Bioorg Med Chem Lett 10: 2171-4 (2001) BindingDB Entry DOI: 10.7270/Q2DB813K
					More data for this Ligand-Target Pair