BDBM50092246 4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid::CHEMBL305748

SMILES: Nc1ncnc2n(C3CCCC3)c(C(O)=O)c(-c3ccc(Oc4ccccc4)cc3)c12

InChI Key: InChIKey=FPIOJWKCVYGQDH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50092246   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50092246 (4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...) Show SMILES Nc1ncnc2n(C3CCCC3)c(C(O)=O)c(-c3ccc(Oc4ccccc4)cc3)c12 Show InChI InChI=1S/C24H22N4O3/c25-22-20-19(15-10-12-18(13-11-15)31-17-8-2-1-3-9-17)21(24(29)30)28(16-6-4-5-7-16)23(20)27-14-26-22/h1-3,8-14,16H,4-7H2,(H,29,30)(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 microM ATP.				Bioorg Med Chem Lett 10: 2171-4 (2001) BindingDB Entry DOI: 10.7270/Q2DB813K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50092246 (4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...) Show SMILES Nc1ncnc2n(C3CCCC3)c(C(O)=O)c(-c3ccc(Oc4ccccc4)cc3)c12 Show InChI InChI=1S/C24H22N4O3/c25-22-20-19(15-10-12-18(13-11-15)31-17-8-2-1-3-9-17)21(24(29)30)28(16-6-4-5-7-16)23(20)27-14-26-22/h1-3,8-14,16H,4-7H2,(H,29,30)(H2,25,26,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.				Bioorg Med Chem Lett 10: 2171-4 (2001) BindingDB Entry DOI: 10.7270/Q2DB813K
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50092246 (4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...) Show SMILES Nc1ncnc2n(C3CCCC3)c(C(O)=O)c(-c3ccc(Oc4ccccc4)cc3)c12 Show InChI InChI=1S/C24H22N4O3/c25-22-20-19(15-10-12-18(13-11-15)31-17-8-2-1-3-9-17)21(24(29)30)28(16-6-4-5-7-16)23(20)27-14-26-22/h1-3,8-14,16H,4-7H2,(H,29,30)(H2,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
BASF Bioresearch Corporation Curated by ChEMBL					Assay Description Inhibitory activity against tie-2 at a concentration of 5 microM ATP.				Bioorg Med Chem Lett 10: 2171-4 (2001) BindingDB Entry DOI: 10.7270/Q2DB813K
					More data for this Ligand-Target Pair