BDBM50092375 1-(3H-Imidazol-4-ylmethyl)-4-methanesulfonyl-7-phenyl-3-pyridin-3-ylmethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine::CHEMBL330945
SMILES: CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1cccnc1)-c1ccccc1
InChI Key: InChIKey=FGDXJSBOTIKISM-RUZDIDTESA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human)) | BDBM50092375 (1-(3H-Imidazol-4-ylmethyl)-4-methanesulfonyl-7-phe...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.95 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of purified recombinant human farnesyltransferase (FT) | J Med Chem 43: 3587-95 (2000) BindingDB Entry DOI: 10.7270/Q2WD3ZSV | |||||||||||
More data for this Ligand-Target Pair |