BDBM50092632 8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline::8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline::CHEMBL127944

SMILES: [O-][N+](=O)c1cccc(c1)-c1cc(Cc2ccncc2)cc2cccnc12

InChI Key: InChIKey=XRSKAWJXBDACRF-UHFFFAOYSA-N

Data: 3 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50092632   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50092632 (8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline ...) Show SMILES [O-][N+](=O)c1cccc(c1)-c1cc(Cc2ccncc2)cc2cccnc12 Show InChI InChI=1S/C21H15N3O2/c25-24(26)19-5-1-3-17(14-19)20-13-16(11-15-6-9-22-10-7-15)12-18-4-2-8-23-21(18)20/h1-10,12-14H,11H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4A expressed in Sf9 cells				J Med Chem 43: 3820-3 (2000) BindingDB Entry DOI: 10.7270/Q23T9GG9
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50092632 (8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline ...) Show SMILES [O-][N+](=O)c1cccc(c1)-c1cc(Cc2ccncc2)cc2cccnc12 Show InChI InChI=1S/C21H15N3O2/c25-24(26)19-5-1-3-17(14-19)20-13-16(11-15-6-9-22-10-7-15)12-18-4-2-8-23-21(18)20/h1-10,12-14H,11H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate				J Med Chem 59: 7029-65 (2016) Article DOI: 10.1021/acs.jmedchem.5b01813
					More data for this Ligand-Target Pair				3D Structure (crystal)
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50092632 (8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline ...) Show SMILES [O-][N+](=O)c1cccc(c1)-c1cc(Cc2ccncc2)cc2cccnc12 Show InChI InChI=1S/C21H15N3O2/c25-24(26)19-5-1-3-17(14-19)20-13-16(11-15-6-9-22-10-7-15)12-18-4-2-8-23-21(18)20/h1-10,12-14H,11H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate				J Med Chem 59: 7029-65 (2016) Article DOI: 10.1021/acs.jmedchem.5b01813
					More data for this Ligand-Target Pair				3D Structure (crystal)