new BindingDB logo
myBDB logout

BDBM50092873 6-Chloro-4-trifluoromethyl-pyridazine-3-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide::CHEMBL128708

SMILES: FC(F)(F)c1cc(NC(=O)c2nnc(Cl)cc2C(F)(F)F)cc(c1)C(F)(F)F

InChI Key: InChIKey=DATQMOXLSOTXFP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50092873   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092873
PNG
(6-Chloro-4-trifluoromethyl-pyridazine-3-carboxylic...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2nnc(Cl)cc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H5ClF9N3O/c15-9-4-8(14(22,23)24)10(27-26-9)11(28)25-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


J Med Chem 57: 6930-48 (2014)


Article DOI: 10.1021/jm5004733
BindingDB Entry DOI: 10.7270/Q2222WDT
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092873
PNG
(6-Chloro-4-trifluoromethyl-pyridazine-3-carboxylic...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2nnc(Cl)cc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H5ClF9N3O/c15-9-4-8(14(22,23)24)10(27-26-9)11(28)25-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)


BindingDB Entry DOI: 10.7270/Q26M363N
More data for this
Ligand-Target Pair