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BDBM50092876 2-Phenyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide::CHEMBL128598

SMILES: FC(F)(F)c1cc(NC(=O)c2cnc(nc2)-c2ccccc2)cc(c1)C(F)(F)F

InChI Key: InChIKey=PGSQZRASNXPXIK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50092876   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50092876
PNG
(2-Phenyl-pyrimidine-5-carboxylic acid (3,5-bis-tri...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(nc2)-c2ccccc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C19H11F6N3O/c20-18(21,22)13-6-14(19(23,24)25)8-15(7-13)28-17(29)12-9-26-16(27-10-12)11-4-2-1-3-5-11/h1-10H,(H,28,29)
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells

J Med Chem 43: 3995-4004 (2000)


BindingDB Entry DOI: 10.7270/Q26M363N
More data for this
Ligand-Target Pair