BDBM50092881 2-Trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide::CHEMBL128053

SMILES: FC(F)(F)c1cc(NC(=O)c2cnc(nc2)C(F)(F)F)cc(c1)C(F)(F)F

InChI Key: InChIKey=MKPSNGLZOZKPDK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50092881   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transcription factor AP-1 (Homo sapiens (Human))	BDBM50092881 (2-Trifluoromethyl-pyrimidine-5-carboxylic acid (3,...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(nc2)C(F)(F)F)cc(c1)C(F)(F)F Show InChI InChI=1S/C14H6F9N3O/c15-12(16,17)7-1-8(13(18,19)20)3-9(2-7)26-10(27)6-4-24-11(25-5-6)14(21,22)23/h1-5H,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells				J Med Chem 43: 3995-4004 (2000) BindingDB Entry DOI: 10.7270/Q26M363N
					More data for this Ligand-Target Pair