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BDBM50092881 2-Trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide::CHEMBL128053

SMILES: FC(F)(F)c1cc(NC(=O)c2cnc(nc2)C(F)(F)F)cc(c1)C(F)(F)F

InChI Key: InChIKey=MKPSNGLZOZKPDK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50092881   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092881
PNG
(2-Trifluoromethyl-pyrimidine-5-carboxylic acid (3,...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(nc2)C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H6F9N3O/c15-12(16,17)7-1-8(13(18,19)20)3-9(2-7)26-10(27)6-4-24-11(25-5-6)14(21,22)23/h1-5H,(H,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)


BindingDB Entry DOI: 10.7270/Q26M363N
More data for this
Ligand-Target Pair