BDBM50092885 2-Cyano-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide::CHEMBL128808

SMILES: FC(F)(F)c1cc(NC(=O)c2cnc(nc2C(F)(F)F)C#N)cc(c1)C(F)(F)F

InChI Key: InChIKey=RIAHUZSRAVBANR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50092885   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transcription factor Jun (Homo sapiens (Human))	BDBM50092885 (2-Cyano-4-trifluoromethyl-pyrimidine-5-carboxylic ...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(nc2C(F)(F)F)C#N)cc(c1)C(F)(F)F Show InChI InChI=1S/C15H5F9N4O/c16-13(17,18)6-1-7(14(19,20)21)3-8(2-6)27-12(29)9-5-26-10(4-25)28-11(9)15(22,23)24/h1-3,5H,(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay				J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT
					More data for this Ligand-Target Pair
Transcription factor Jun (Homo sapiens (Human))	BDBM50092885 (2-Cyano-4-trifluoromethyl-pyrimidine-5-carboxylic ...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(nc2C(F)(F)F)C#N)cc(c1)C(F)(F)F Show InChI InChI=1S/C15H5F9N4O/c16-13(17,18)6-1-7(14(19,20)21)3-8(2-6)27-12(29)9-5-26-10(4-25)28-11(9)15(22,23)24/h1-3,5H,(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells				J Med Chem 43: 3995-4004 (2000) BindingDB Entry DOI: 10.7270/Q26M363N
					More data for this Ligand-Target Pair