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BDBM50092886 2-Chloro-4-thiophen-2-yl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide::CHEMBL128599

SMILES: FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2-c2cccs2)cc(c1)C(F)(F)F

InChI Key: InChIKey=IAXBEEZQRRFFDT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50092886   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50092886
PNG
(2-Chloro-4-thiophen-2-yl-pyrimidine-5-carboxylic a...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2-c2cccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C17H8ClF6N3OS/c18-15-25-7-11(13(27-15)12-2-1-3-29-12)14(28)26-10-5-8(16(19,20)21)4-9(6-10)17(22,23)24/h1-7H,(H,26,28)
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells

J Med Chem 43: 3995-4004 (2000)


BindingDB Entry DOI: 10.7270/Q26M363N
More data for this
Ligand-Target Pair