BDBM50093215 1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-isoxazol-5-ylmethyl}-piperidin-2-one::CHEMBL421324
SMILES: CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)on2)CC1
InChI Key: InChIKey=DSMKEQAYQKRDDL-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50093215 (1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1A adrenergic receptor | Bioorg Med Chem Lett 10: 2375-7 (2001) BindingDB Entry DOI: 10.7270/Q2D50M66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50093215 (1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 272 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor | Bioorg Med Chem Lett 10: 2375-7 (2001) BindingDB Entry DOI: 10.7270/Q2D50M66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic alpha1B (Homo sapiens (Human)) | BDBM50093215 (1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards COS cell membrane expressing the human Alpha-1B adrenergic receptor | Bioorg Med Chem Lett 10: 2375-7 (2001) BindingDB Entry DOI: 10.7270/Q2D50M66 | |||||||||||
More data for this Ligand-Target Pair |