BDBM50093255 (+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one]::(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one]::1'-azaspiro[oxazolidine-5,3'-bicyclo[2.2.2]octan]-2-one::2'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazolidin]-2'-one::CHEMBL293975::Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one]
SMILES: O=C1NCC2(CN3CCC2CC3)O1
InChI Key: InChIKey=TYAGAVRSOFABFO-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 92 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description binding affinity in rat hippocampi against alpha7 nicotinic receptor | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description binding affinity in rat hippocampi against alpha7 nicotinic receptor | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation Curated by ChEMBL | Assay Description Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7 | J Med Chem 48: 2678-86 (2005) Article DOI: 10.1021/jm049188d BindingDB Entry DOI: 10.7270/Q2M0466W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description binding affinity in rat hippocampi against alpha7 nicotinic receptor | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description binding affinity in rat forebrain against alpha4-beta2 nicotinic receptor | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description binding affinity in rat forebrain against alpha4-beta2 nicotinic receptor | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR | J Med Chem 51: 6293-302 (2008) Article DOI: 10.1021/jm800607u BindingDB Entry DOI: 10.7270/Q2NZ88JP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Agonist activity at human cloned wild-type alpha7 nAChR expressed in Xenopus laevis oocytes assessed as channel opening by voltage clamp electrophysi... | J Med Chem 51: 6293-302 (2008) Article DOI: 10.1021/jm800607u BindingDB Entry DOI: 10.7270/Q2NZ88JP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit (Homo sapiens (Human)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes | J Med Chem 48: 4705-45 (2005) Article DOI: 10.1021/jm040219e BindingDB Entry DOI: 10.7270/Q29W0G79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.10E+7 | n/a | n/a | n/a | n/a |
AstraZeneca R&D Boston Curated by ChEMBL | Assay Description Potency was determined by measuring current activation in Xenopus oocytes expressing rat alpha7 nAChRs | J Med Chem 43: 4045-50 (2000) BindingDB Entry DOI: 10.7270/Q24Q7T88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human)) | BDBM50093255 ((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Agonist activity at human recombinant alpha7 nAChR expressed in rat GH3 cells by calcium influx assay | Bioorg Med Chem Lett 19: 1287-91 (2009) Article DOI: 10.1016/j.bmcl.2009.01.073 BindingDB Entry DOI: 10.7270/Q2GM875B | |||||||||||
More data for this Ligand-Target Pair |