BDBM50094092 CHEMBL336661::N-(3-Bromo-2'-sulfamoyl-biphenyl-4-yl)-2-(5-carbamimidoyl-1H-indol-3-yl)-acetamide
SMILES: NC(=N)c1ccc2[nH]cc(CC(=O)Nc3ccc(cc3Br)-c3ccccc3S(N)(=O)=O)c2c1
InChI Key: InChIKey=OILPCJZAWDBHHE-UHFFFAOYSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor X (Homo sapiens (Human)) | BDBM50094092 (CHEMBL336661 | N-(3-Bromo-2'-sulfamoyl-biphenyl-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Binding affinity against human coagulation factor X | J Med Chem 43: 4398-415 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50094092 (CHEMBL336661 | N-(3-Bromo-2'-sulfamoyl-biphenyl-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Binding affinity against Coagulation factor X from rabbit purified enzyme | J Med Chem 43: 4398-415 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin-1 (Homo sapiens (Human)) | BDBM50094092 (CHEMBL336661 | N-(3-Bromo-2'-sulfamoyl-biphenyl-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Binding affinity against human trypsin | J Med Chem 43: 4398-415 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50094092 (CHEMBL336661 | N-(3-Bromo-2'-sulfamoyl-biphenyl-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Binding affinity against human thrombin | J Med Chem 43: 4398-415 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PP5 | |||||||||||
More data for this Ligand-Target Pair |