BDBM50094278 4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidin-2-one::CHEMBL341739

SMILES: Cc1cn([C@H]2C[C@@H](O)[C@@](CO)(O2)C#C)c(=O)nc1N

InChI Key: InChIKey=WTXZTUMDRHBSQE-KBVBSXBZSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50094278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50094278 (4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tet...) Show SMILES Cc1cn([C@H]2C[C@@H](O)[C@@](CO)(O2)C#C)c(=O)nc1N Show InChI InChI=1S/C12H15N3O4/c1-3-12(6-16)8(17)4-9(19-12)15-5-7(2)10(13)14-11(15)18/h1,5,8-9,16-17H,4,6H2,2H3,(H2,13,14,18)/t8-,9-,12-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Tohoku University Curated by ChEMBL					Assay Description Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assay				J Med Chem 43: 4516-25 (2000) BindingDB Entry DOI: 10.7270/Q2GM881Z
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50094278 (4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tet...) Show SMILES Cc1cn([C@H]2C[C@@H](O)[C@@](CO)(O2)C#C)c(=O)nc1N Show InChI InChI=1S/C12H15N3O4/c1-3-12(6-16)8(17)4-9(19-12)15-5-7(2)10(13)14-11(15)18/h1,5,8-9,16-17H,4,6H2,2H3,(H2,13,14,18)/t8-,9-,12-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a
Tohoku University Curated by ChEMBL					Assay Description Tested in vitro against HIV-1 MDR using MAGI assay				J Med Chem 43: 4516-25 (2000) BindingDB Entry DOI: 10.7270/Q2GM881Z
					More data for this Ligand-Target Pair