Found 4 hits for monomerid = 50094308 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50094308
(CHEMBL3590114)Show SMILES CNC(=O)c1ccc(F)cc1Nc1cc(Nc2cc(C)nn2C)ncc1C(F)(F)F Show InChI InChI=1S/C23H41N5O3/c1-2-8-22(30)28-21(18-19-9-5-10-20(29)17-19)23(31)27-16-7-15-26-13-4-3-12-25-14-6-11-24/h5,9-10,17,21,25-26,29H,2-4,6-8,11-16,18,24H2,1H3,(H,27,31)(H,28,30)/t21-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V... |
J Med Chem 58: 4790-801 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00466 BindingDB Entry DOI: 10.7270/Q2V989SJ |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50094308
(CHEMBL3590114)Show SMILES CNC(=O)c1ccc(F)cc1Nc1cc(Nc2cc(C)nn2C)ncc1C(F)(F)F Show InChI InChI=1S/C23H41N5O3/c1-2-8-22(30)28-21(18-19-9-5-10-20(29)17-19)23(31)27-16-7-15-26-13-4-3-12-25-14-6-11-24/h5,9-10,17,21,25-26,29H,2-4,6-8,11-16,18,24H2,1H3,(H,27,31)(H,28,30)/t21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) autophosphorylation incubated with enzyme for 20 mins prior to ATP addition by ADP Glo kinase assay in presence o... |
J Med Chem 58: 4790-801 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00466 BindingDB Entry DOI: 10.7270/Q2V989SJ |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50094308
(CHEMBL3590114)Show SMILES CNC(=O)c1ccc(F)cc1Nc1cc(Nc2cc(C)nn2C)ncc1C(F)(F)F Show InChI InChI=1S/C23H41N5O3/c1-2-8-22(30)28-21(18-19-9-5-10-20(29)17-19)23(31)27-16-7-15-26-13-4-3-12-25-14-6-11-24/h5,9-10,17,21,25-26,29H,2-4,6-8,11-16,18,24H2,1H3,(H,27,31)(H,28,30)/t21-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by... |
J Med Chem 58: 4790-801 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00466 BindingDB Entry DOI: 10.7270/Q2V989SJ |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50094308
(CHEMBL3590114)Show SMILES CNC(=O)c1ccc(F)cc1Nc1cc(Nc2cc(C)nn2C)ncc1C(F)(F)F Show InChI InChI=1S/C23H41N5O3/c1-2-8-22(30)28-21(18-19-9-5-10-20(29)17-19)23(31)27-16-7-15-26-13-4-3-12-25-14-6-11-24/h5,9-10,17,21,25-26,29H,2-4,6-8,11-16,18,24H2,1H3,(H,27,31)(H,28,30)/t21-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by... |
J Med Chem 58: 4790-801 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00466 BindingDB Entry DOI: 10.7270/Q2V989SJ |
More data for this Ligand-Target Pair | |