BDBM50094597 CHEMBL2323028

SMILES: OC(=O)c1cc(on1)-c1ccc(Oc2ccc(Cl)cc2)cc1

InChI Key: InChIKey=SBUKOIGPSJXGBL-GMAHTHKFSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50094597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Catenin beta-1 (Homo sapiens (Human))	BDBM50094597 (CHEMBL2323028) Show SMILES OC(=O)c1cc(on1)-c1ccc(Oc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C30H30N4/c1-20-22(3)34(23(4)25-16-10-6-11-17-25)30-27(20)29(31-21(2)24-14-8-5-9-15-24)32-28(33-30)26-18-12-7-13-19-26/h5-19,21,23H,1-4H3,(H,31,32,33)/t21-,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of N-terminally His6-tagged human beta-catenin (residues 138-686)/C-terminally biotinylated human Tcf4 (residues 7-51) interaction after 4...				J Med Chem 58: 4678-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00223 BindingDB Entry DOI: 10.7270/Q2G44S28
					More data for this Ligand-Target Pair
Transcription factor 7-like 2 (Homo sapiens (Human))	BDBM50094597 (CHEMBL2323028) Show SMILES OC(=O)c1cc(on1)-c1ccc(Oc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C30H30N4/c1-20-22(3)34(23(4)25-16-10-6-11-17-25)30-27(20)29(31-21(2)24-14-8-5-9-15-24)32-28(33-30)26-18-12-7-13-19-26/h5-19,21,23H,1-4H3,(H,31,32,33)/t21-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of human beta-casein/Tcf4 interaction after 1 hr by alphascreen assay				ACS Med Chem Lett 4: 306-11 (2013) Article DOI: 10.1021/ml300367f BindingDB Entry DOI: 10.7270/Q2CN76TG
					More data for this Ligand-Target Pair
Transcription factor 7-like 2 (Homo sapiens (Human))	BDBM50094597 (CHEMBL2323028) Show SMILES OC(=O)c1cc(on1)-c1ccc(Oc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C30H30N4/c1-20-22(3)34(23(4)25-16-10-6-11-17-25)30-27(20)29(31-21(2)24-14-8-5-9-15-24)32-28(33-30)26-18-12-7-13-19-26/h5-19,21,23H,1-4H3,(H,31,32,33)/t21-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of human beta-casein/Tcf4 interaction after 1 hr by fluorescence polarization assay				ACS Med Chem Lett 4: 306-11 (2013) Article DOI: 10.1021/ml300367f BindingDB Entry DOI: 10.7270/Q2CN76TG
					More data for this Ligand-Target Pair
Catenin beta-1 (Homo sapiens (Human))	BDBM50094597 (CHEMBL2323028) Show SMILES OC(=O)c1cc(on1)-c1ccc(Oc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C30H30N4/c1-20-22(3)34(23(4)25-16-10-6-11-17-25)30-27(20)29(31-21(2)24-14-8-5-9-15-24)32-28(33-30)26-18-12-7-13-19-26/h5-19,21,23H,1-4H3,(H,31,32,33)/t21-,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after...				J Med Chem 58: 4678-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00223 BindingDB Entry DOI: 10.7270/Q2G44S28
					More data for this Ligand-Target Pair