BDBM50094600 CHEMBL2323029

SMILES: OC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c(nc2c1)-c1ccc(Cl)cc1

InChI Key: InChIKey=MYTZJXIHAJYXDZ-SFHVURJKSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50094600   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transcription factor 7-like 2 (Homo sapiens (Human))	BDBM50094600 (CHEMBL2323029) Show SMILES OC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c(nc2c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H27N5/c1-16-17(2)29(18(3)19-10-6-4-7-11-19)24-21(16)23(26-15-14-25)27-22(28-24)20-12-8-5-9-13-20/h4-13,18H,14-15,25H2,1-3H3,(H,26,27,28)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of human beta-casein/Tcf4 interaction after 1 hr by fluorescence polarization assay				ACS Med Chem Lett 4: 306-11 (2013) Article DOI: 10.1021/ml300367f BindingDB Entry DOI: 10.7270/Q2CN76TG
					More data for this Ligand-Target Pair
Catenin beta-1 (Homo sapiens (Human))	BDBM50094600 (CHEMBL2323029) Show SMILES OC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c(nc2c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H27N5/c1-16-17(2)29(18(3)19-10-6-4-7-11-19)24-21(16)23(26-15-14-25)27-22(28-24)20-12-8-5-9-13-20/h4-13,18H,14-15,25H2,1-3H3,(H,26,27,28)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after...				J Med Chem 58: 4678-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00223 BindingDB Entry DOI: 10.7270/Q2G44S28
					More data for this Ligand-Target Pair
Transcription factor 7-like 2 (Homo sapiens (Human))	BDBM50094600 (CHEMBL2323029) Show SMILES OC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c(nc2c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H27N5/c1-16-17(2)29(18(3)19-10-6-4-7-11-19)24-21(16)23(26-15-14-25)27-22(28-24)20-12-8-5-9-13-20/h4-13,18H,14-15,25H2,1-3H3,(H,26,27,28)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of human beta-casein/Tcf4 interaction after 1 hr by alphascreen assay				ACS Med Chem Lett 4: 306-11 (2013) Article DOI: 10.1021/ml300367f BindingDB Entry DOI: 10.7270/Q2CN76TG
					More data for this Ligand-Target Pair
Catenin beta-1 (Homo sapiens (Human))	BDBM50094600 (CHEMBL2323029) Show SMILES OC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c(nc2c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H27N5/c1-16-17(2)29(18(3)19-10-6-4-7-11-19)24-21(16)23(26-15-14-25)27-22(28-24)20-12-8-5-9-13-20/h4-13,18H,14-15,25H2,1-3H3,(H,26,27,28)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of N-terminally His6-tagged human beta-catenin (residues 138-686)/C-terminally biotinylated human Tcf4 (residues 7-51) interaction after 4...				J Med Chem 58: 4678-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00223 BindingDB Entry DOI: 10.7270/Q2G44S28
					More data for this Ligand-Target Pair