BDBM50094602 CHEMBL3589010::US9284299, iCRT14::US9738628, Compound iCRT14
SMILES: Cc1cc(\C=C2/SC(=O)N(C2=O)c2ccccc2)c(C)n1-c1cccnc1
InChI Key: InChIKey=SIWILKNHDXXHHI-FQEVSTJZSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Catenin beta-1 [138-686] (Homo sapiens (Human)) | BDBM50094602 (CHEMBL3589010 | US9284299, iCRT14 | US9738628, Com...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | 4.07E+4 | -5.99 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Utah Research Foundation US Patent | Assay Description Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (... | US Patent US9284299 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GGC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Catenin beta-1 [138-686] (Homo sapiens (Human)) | BDBM50094602 (CHEMBL3589010 | US9284299, iCRT14 | US9738628, Com...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | 4.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah Research Foundation US Patent | Assay Description Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino... | US Patent US9738628 (2017) BindingDB Entry DOI: 10.7270/Q27P91H7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Catenin beta-1 [138-686] (Homo sapiens (Human)) | BDBM50094602 (CHEMBL3589010 | US9284299, iCRT14 | US9738628, Com...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | 5.35E+4 | -5.82 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
University of Utah Research Foundation US Patent | Assay Description Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino... | US Patent US9284299 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GGC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Catenin beta-1 [138-686] (Homo sapiens (Human)) | BDBM50094602 (CHEMBL3589010 | US9284299, iCRT14 | US9738628, Com...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | 5.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah Research Foundation US Patent | Assay Description Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (... | US Patent US9738628 (2017) BindingDB Entry DOI: 10.7270/Q27P91H7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Catenin beta-1 (Homo sapiens (Human)) | BDBM50094602 (CHEMBL3589010 | US9284299, iCRT14 | US9738628, Com...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 5.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah Curated by ChEMBL | Assay Description Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after... | J Med Chem 58: 4678-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00223 BindingDB Entry DOI: 10.7270/Q2G44S28 | |||||||||||
More data for this Ligand-Target Pair |