BDBM50095049 3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole::3-(1-phenethylpiperidin-4-yl)-2-phenyl-1H-indole::CHEMBL40584
SMILES: C(Cc1ccccc1)N1CCC(CC1)c1c([nH]c2ccccc12)-c1ccccc1
InChI Key: InChIKey=MONKRYYJEIHBRU-UHFFFAOYSA-N
Data: 6 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50095049 (3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.480 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Ability to displace [3H]-ketanserin binding to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells | J Med Chem 44: 1603-14 (2001) BindingDB Entry DOI: 10.7270/Q27M076K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50095049 (3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cells | Bioorg Med Chem Lett 10: 2701-3 (2000) BindingDB Entry DOI: 10.7270/Q23J3C7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50095049 (3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Ability to displace [3H]-mesulergine binding to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cells | J Med Chem 44: 1603-14 (2001) BindingDB Entry DOI: 10.7270/Q27M076K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50095049 (3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human ERG channel | J Med Chem 52: 4266-76 (2009) Article DOI: 10.1021/jm900002x BindingDB Entry DOI: 10.7270/Q2MK6DT2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50095049 (3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Displacement of [3H]-dofetilide from HEK cells expressing hERG voltage dependent IKr potassium channel Kv11.1 | J Med Chem 44: 1603-14 (2001) BindingDB Entry DOI: 10.7270/Q27M076K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50095049 (3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Ability to displace [3H]-spiperone binding to CHO cells stably expressing dopamine receptor D2 | J Med Chem 44: 1603-14 (2001) BindingDB Entry DOI: 10.7270/Q27M076K | |||||||||||
More data for this Ligand-Target Pair |