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BDBM50095227 (6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)-amine::6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine::CHEMBL97771

SMILES: COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC

InChI Key: InChIKey=DMWVGXGXHPOEPT-UHFFFAOYSA-N

Data: 4 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50095227   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-B receptor 2


(Homo sapiens (Human))
BDBM50095227
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Show SMILES COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
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n/an/a 8.60E+4n/an/an/an/an/an/a



Protana Inc.

Curated by ChEMBL


Assay Description
Inhibition of EPH receptor B2 using ELISA


J Med Chem 48: 3221-30 (2005)


Article DOI: 10.1021/jm0492204
BindingDB Entry DOI: 10.7270/Q2DF6QRN
More data for this
Ligand-Target Pair
Ephrin type-B receptor 2


(Homo sapiens (Human))
BDBM50095227
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Show SMILES COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
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PubMed
n/an/an/a 5.84E+4n/an/an/an/an/a



Protana Inc.

Curated by ChEMBL


Assay Description
Equilibrium binding constant for EPH receptor B2


J Med Chem 48: 3221-30 (2005)


Article DOI: 10.1021/jm0492204
BindingDB Entry DOI: 10.7270/Q2DF6QRN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK)


(Homo sapiens (Human))
BDBM50095227
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Show SMILES COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL




Bioorg Med Chem Lett 10: 2825-8 (2000)


BindingDB Entry DOI: 10.7270/Q22N51J8
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Gallus gallus (Chicken))
BDBM50095227
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Show SMILES COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
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n/an/a 180n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of Src in the presence of 50uM ATP


Biochem J 408: 297-315 (2007)


Article DOI: 10.1042/BJ20070797
BindingDB Entry DOI: 10.7270/Q27082B4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM50095227
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Show SMILES COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 26n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of RIP2 in the presence of 100uM ATP


Biochem J 408: 297-315 (2007)


Article DOI: 10.1042/BJ20070797
BindingDB Entry DOI: 10.7270/Q27082B4
More data for this
Ligand-Target Pair