BDBM50095420 5-tert-Butyl-3-[3-(4-chloro-phenyl)-ureido]-thiophene-2-carboxylic acid methyl ester::CHEMBL278737

SMILES: COC(=O)c1sc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C

InChI Key: InChIKey=OQCCZKUFFXQPQV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50095420   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50095420 (5-tert-Butyl-3-[3-(4-chloro-phenyl)-ureido]-thioph...) Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C Show InChI InChI=1S/C17H19ClN2O3S/c1-17(2,3)13-9-12(14(24-13)15(21)23-4)20-16(22)19-11-7-5-10(18)6-8-11/h5-9H,1-4H3,(H2,19,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory concentration against raf kinase.				Bioorg Med Chem Lett 11: 2775-8 (2001) BindingDB Entry DOI: 10.7270/Q2NS0VD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50095420 (5-tert-Butyl-3-[3-(4-chloro-phenyl)-ureido]-thioph...) Show SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C Show InChI InChI=1S/C17H19ClN2O3S/c1-17(2,3)13-9-12(14(24-13)15(21)23-4)20-16(22)19-11-7-5-10(18)6-8-11/h5-9H,1-4H3,(H2,19,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli				Bioorg Med Chem Lett 11: 9-12 (2001) BindingDB Entry DOI: 10.7270/Q2JM28WH
					More data for this Ligand-Target Pair