Found 4 hits for monomerid = 50095953 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50095953
(CHEMBL3593776)Show SMILES NC(=O)c1cnc2[nH]ccc2c1NC1CCN(CC1)c1ccc(nn1)C#N Show InChI InChI=1S/C21H30N6O6/c1-3-23-19(30)16-14(28)15(29)20(33-16)27-9-24-13-17(22)25-12(26-18(13)27)8-10-4-6-11(7-5-10)21(31)32-2/h9-11,14-16,20,28-29H,3-8H2,1-2H3,(H,23,30)(H2,22,25,26)/t10?,11?,14-,15+,16+,20?/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG expressed in CHOK1 cells incubated for 10 mins by Rb efflux assay |
Bioorg Med Chem 23: 4871-83 (2015)
Article DOI: 10.1016/j.bmc.2015.05.034
BindingDB Entry DOI: 10.7270/Q2DZ0B21 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50095953
(CHEMBL3593776)Show SMILES NC(=O)c1cnc2[nH]ccc2c1NC1CCN(CC1)c1ccc(nn1)C#N Show InChI InChI=1S/C21H30N6O6/c1-3-23-19(30)16-14(28)15(29)20(33-16)27-9-24-13-17(22)25-12(26-18(13)27)8-10-4-6-11(7-5-10)21(31)32-2/h9-11,14-16,20,28-29H,3-8H2,1-2H3,(H,23,30)(H2,22,25,26)/t10?,11?,14-,15+,16+,20?/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA method |
Bioorg Med Chem 23: 4871-83 (2015)
Article DOI: 10.1016/j.bmc.2015.05.034
BindingDB Entry DOI: 10.7270/Q2DZ0B21 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50095953
(CHEMBL3593776)Show SMILES NC(=O)c1cnc2[nH]ccc2c1NC1CCN(CC1)c1ccc(nn1)C#N Show InChI InChI=1S/C21H30N6O6/c1-3-23-19(30)16-14(28)15(29)20(33-16)27-9-24-13-17(22)25-12(26-18(13)27)8-10-4-6-11(7-5-10)21(31)32-2/h9-11,14-16,20,28-29H,3-8H2,1-2H3,(H,23,30)(H2,22,25,26)/t10?,11?,14-,15+,16+,20?/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA method |
Bioorg Med Chem 23: 4871-83 (2015)
Article DOI: 10.1016/j.bmc.2015.05.034
BindingDB Entry DOI: 10.7270/Q2DZ0B21 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50095953
(CHEMBL3593776)Show SMILES NC(=O)c1cnc2[nH]ccc2c1NC1CCN(CC1)c1ccc(nn1)C#N Show InChI InChI=1S/C21H30N6O6/c1-3-23-19(30)16-14(28)15(29)20(33-16)27-9-24-13-17(22)25-12(26-18(13)27)8-10-4-6-11(7-5-10)21(31)32-2/h9-11,14-16,20,28-29H,3-8H2,1-2H3,(H,23,30)(H2,22,25,26)/t10?,11?,14-,15+,16+,20?/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA method |
Bioorg Med Chem 23: 4871-83 (2015)
Article DOI: 10.1016/j.bmc.2015.05.034
BindingDB Entry DOI: 10.7270/Q2DZ0B21 |
More data for this
Ligand-Target Pair | |
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