Found 9 hits for monomerid = 50095997 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage migration inhibitory factor (MIF)
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
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UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd.
Curated by ChEMBL
| Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) |
J Med Chem 44: 540-7 (2001)
BindingDB Entry DOI: 10.7270/Q2W66MGR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor (MIF)
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
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UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MIF tautomerase |
J Med Chem 52: 416-24 (2009)
Article DOI: 10.1021/jm801100v BindingDB Entry DOI: 10.7270/Q208656D |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor (MIF)
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
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UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
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| MMDB PDB PubMed
| 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli using 4-hydroxyphenyl pyruvic acid as substrate assessed as bo... |
Bioorg Med Chem Lett 26: 2764-2767 (2016)
BindingDB Entry DOI: 10.7270/Q24X59PR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor (MIF)
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
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UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His-tagged MIF tautomerization expressed in Escherichia coli BL21 (DE3) using D-dopachrome as substrate after 10 mins... |
J Med Chem 61: 8104-8119 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00589 BindingDB Entry DOI: 10.7270/Q2KS6V5P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosinase
(Mus musculus (Mouse)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 5.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AmorePacific Corporation
Curated by ChEMBL
| Assay Description Inhibition of tyrosinase in mouse Melan-a cells by ELISA |
Bioorg Med Chem Lett 20: 1162-4 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.021 BindingDB Entry DOI: 10.7270/Q2M045JZ |
More data for this Ligand-Target Pair | |
Xanthine dehydrogenase/oxidase
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AmorePacific Corporation
Curated by ChEMBL
| Assay Description Inhibition of xanthine oxidase (unknown origin) assessed as decrease of uric acid generation |
Bioorg Med Chem Lett 18: 5006-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.016 BindingDB Entry DOI: 10.7270/Q2QF8SQK |
More data for this Ligand-Target Pair | |
Xanthine dehydrogenase/oxidase
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.68E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AmorePacific Corporation
Curated by ChEMBL
| Assay Description Inhibition of xanthine oxidase (unknown origin) assessed as decrease of superoxide generation |
Bioorg Med Chem Lett 18: 5006-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.016 BindingDB Entry DOI: 10.7270/Q2QF8SQK |
More data for this Ligand-Target Pair | |
Death-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 2.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assay |
J Med Chem 58: 7400-8 (2015)
BindingDB Entry DOI: 10.7270/Q21838BM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor (MIF)
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity expressed in Escherichia coli BL21 (DE3) using 4-hydroxyphenyl pyruvic acid as substrate |
Bioorg Med Chem Lett 26: 2764-2767 (2016)
BindingDB Entry DOI: 10.7270/Q24X59PR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |