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BDBM50096459 1-(3-Carbamimidoyl-benzyl)-4-hydroxy-1H-indole-2-carboxylic acid 3,5-dichloro-benzylamide::CHEMBL75544

SMILES: NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cc(Cl)cc(Cl)c2)c1

InChI Key: InChIKey=FCFGTZIDSYBJHD-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50096459   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM50096459
PNG
(1-(3-Carbamimidoyl-benzyl)-4-hydroxy-1H-indole-2-c...)
Show SMILES NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cc(Cl)cc(Cl)c2)c1
Show InChI InChI=1S/C24H20Cl2N4O2/c25-17-8-15(9-18(26)10-17)12-29-24(32)21-11-19-20(5-2-6-22(19)31)30(21)13-14-3-1-4-16(7-14)23(27)28/h1-11,31H,12-13H2,(H3,27,28)(H,29,32)
PDB
MMDB

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UniProtKB/SwissProt

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DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
PubMed
5n/an/an/an/an/an/an/an/a



Aventis Pharma

Curated by ChEMBL


Assay Description
Inhibitory activity against serine protease factor Xa (fXa) was determined


Bioorg Med Chem Lett 11: 227-30 (2001)


BindingDB Entry DOI: 10.7270/Q2KD1X68
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50096459
PNG
(1-(3-Carbamimidoyl-benzyl)-4-hydroxy-1H-indole-2-c...)
Show SMILES NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cc(Cl)cc(Cl)c2)c1
Show InChI InChI=1S/C24H20Cl2N4O2/c25-17-8-15(9-18(26)10-17)12-29-24(32)21-11-19-20(5-2-6-22(19)31)30(21)13-14-3-1-4-16(7-14)23(27)28/h1-11,31H,12-13H2,(H3,27,28)(H,29,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
771n/an/an/an/an/an/an/an/a



Aventis Pharma

Curated by ChEMBL


Assay Description
Inhibitory activity against thrombin was determined


Bioorg Med Chem Lett 11: 227-30 (2001)


BindingDB Entry DOI: 10.7270/Q2KD1X68
More data for this
Ligand-Target Pair