BDBM50097100 2-Phenyl-quinoline-4-carboxylic acid::2-phenylquinoline-4-carboxylic acid::CHEMBL348000::Cinchophen
SMILES: OC(=O)c1cc(nc2ccccc12)-c1ccccc1
InChI Key: InChIKey=YTRMTPPVNRALON-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Prolyl-tRNA synthetase (Candida albicans) | BDBM50097100 (2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Aminoacylation activity against Candida albicans prolyl-tRNA synthetase | Bioorg Med Chem Lett 11: 541-4 (2001) BindingDB Entry DOI: 10.7270/Q2Q23ZH8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminoacyl-tRNA synthetase (Homo sapiens (Human)) | BDBM50097100 (2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Aminoacylation activity against human prolyl-tRNA synthetase | Bioorg Med Chem Lett 11: 541-4 (2001) BindingDB Entry DOI: 10.7270/Q2Q23ZH8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (BSEP) (Homo sapiens (Human)) | BDBM50097100 (2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.95E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake | Drug Metab Dispos 40: 130-8 (2011) Article DOI: 10.1124/dmd.111.040758 BindingDB Entry DOI: 10.7270/Q20Z7500 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (Homo sapiens (Human)) | BDBM50097100 (2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.44E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of DHODH (unknown origin) expressed in Escherichia coli Rosetta2(DE3) assessed as reduction of DCIP using dihydroorotate as substrate prei... | J Med Chem 61: 5162-5186 (2018) Article DOI: 10.1021/acs.jmedchem.7b01862 BindingDB Entry DOI: 10.7270/Q2JS9T36 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50097100 (2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.27E+5 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to human PDE10A catalytic domain expressed in Escherichia coli BL21-Gold(DE3) after 15 mins by SPR inhibition in solution assay | J Med Chem 56: 3228-34 (2013) Article DOI: 10.1021/jm301665y BindingDB Entry DOI: 10.7270/Q2G1625N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Homo sapiens (Human)) | BDBM50097100 (2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >8.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... | Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Rattus norvegicus) | BDBM50097100 (2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.96E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up... | Drug Metab Dispos 40: 130-8 (2011) Article DOI: 10.1124/dmd.111.040758 BindingDB Entry DOI: 10.7270/Q20Z7500 | |||||||||||
More data for this Ligand-Target Pair |