BDBM50097239 (R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethyl-propyl]-N*4*-hydroxy-2-(3-phenyl-propyl)-succinamide::(R)-N1-((S)-1-(benzhydrylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide::CHEMBL436230

SMILES: CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1

InChI Key: InChIKey=HMXIGWYKQCGDNX-GGXMVOPNSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50097239   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Stromelysin-1 (Homo sapiens (Human))	BDBM50097239 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H39N3O4/c1-32(2,3)29(31(38)33-28(24-17-9-5-10-18-24)25-19-11-6-12-20-25)34-30(37)26(22-27(36)35-39)21-13-16-23-14-7-4-8-15-23/h4-12,14-15,17-20,26,28-29,39H,13,16,21-22H2,1-3H3,(H,33,38)(H,34,37)(H,35,36)/t26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Ability to inhibit the matrix metalloprotease-3 by method of Knight et al using the fluorogenic peptide substrate.				Bioorg Med Chem Lett 11: 567-70 (2001) BindingDB Entry DOI: 10.7270/Q2610ZK1
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50097239 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H39N3O4/c1-32(2,3)29(31(38)33-28(24-17-9-5-10-18-24)25-19-11-6-12-20-25)34-30(37)26(22-27(36)35-39)21-13-16-23-14-7-4-8-15-23/h4-12,14-15,17-20,26,28-29,39H,13,16,21-22H2,1-3H3,(H,33,38)(H,34,37)(H,35,36)/t26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	414	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Ability to inhibit the matrix metalloprotease-2 by method of Knight et al using the fluorogenic peptide substrate.				Bioorg Med Chem Lett 11: 567-70 (2001) BindingDB Entry DOI: 10.7270/Q2610ZK1
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50097239 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H39N3O4/c1-32(2,3)29(31(38)33-28(24-17-9-5-10-18-24)25-19-11-6-12-20-25)34-30(37)26(22-27(36)35-39)21-13-16-23-14-7-4-8-15-23/h4-12,14-15,17-20,26,28-29,39H,13,16,21-22H2,1-3H3,(H,33,38)(H,34,37)(H,35,36)/t26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	417	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50097239 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H39N3O4/c1-32(2,3)29(31(38)33-28(24-17-9-5-10-18-24)25-19-11-6-12-20-25)34-30(37)26(22-27(36)35-39)21-13-16-23-14-7-4-8-15-23/h4-12,14-15,17-20,26,28-29,39H,13,16,21-22H2,1-3H3,(H,33,38)(H,34,37)(H,35,36)/t26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	414	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Concentration required to inhibit the catalytic domain Matrix metalloprotease-2 using Nagase fluorogenic as a substrate.				Bioorg Med Chem Lett 11: 571-4 (2001) BindingDB Entry DOI: 10.7270/Q22B8X9X
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50097239 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H39N3O4/c1-32(2,3)29(31(38)33-28(24-17-9-5-10-18-24)25-19-11-6-12-20-25)34-30(37)26(22-27(36)35-39)21-13-16-23-14-7-4-8-15-23/h4-12,14-15,17-20,26,28-29,39H,13,16,21-22H2,1-3H3,(H,33,38)(H,34,37)(H,35,36)/t26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50097239 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H39N3O4/c1-32(2,3)29(31(38)33-28(24-17-9-5-10-18-24)25-19-11-6-12-20-25)34-30(37)26(22-27(36)35-39)21-13-16-23-14-7-4-8-15-23/h4-12,14-15,17-20,26,28-29,39H,13,16,21-22H2,1-3H3,(H,33,38)(H,34,37)(H,35,36)/t26-,29-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Concentration required to inhibit the catalytic domain Matrix metalloprotease-3 using Nagase fluorogenic as a substrate.				Bioorg Med Chem Lett 11: 571-4 (2001) BindingDB Entry DOI: 10.7270/Q22B8X9X
					More data for this Ligand-Target Pair