BDBM50097268 (R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethyl-propyl]-2-(3-biphenyl-4-yl-propyl)-N*4*-hydroxy-succinamide::CHEMBL154440

SMILES: CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccc(cc1)-c1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1

InChI Key: InChIKey=YWZDVYPIFZUSBG-FHPVIJFVSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50097268   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Stromelysin-1 (Homo sapiens (Human))	BDBM50097268 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccc(cc1)-c1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C38H43N3O4/c1-38(2,3)35(37(44)39-34(30-17-9-5-10-18-30)31-19-11-6-12-20-31)40-36(43)32(26-33(42)41-45)21-13-14-27-22-24-29(25-23-27)28-15-7-4-8-16-28/h4-12,15-20,22-25,32,34-35,45H,13-14,21,26H2,1-3H3,(H,39,44)(H,40,43)(H,41,42)/t32-,35-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Concentration required to inhibit the catalytic domain Matrix metalloprotease-3 using Nagase fluorogenic as a substrate.				Bioorg Med Chem Lett 11: 571-4 (2001) BindingDB Entry DOI: 10.7270/Q22B8X9X
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50097268 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccc(cc1)-c1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C38H43N3O4/c1-38(2,3)35(37(44)39-34(30-17-9-5-10-18-30)31-19-11-6-12-20-31)40-36(43)32(26-33(42)41-45)21-13-14-27-22-24-29(25-23-27)28-15-7-4-8-16-28/h4-12,15-20,22-25,32,34-35,45H,13-14,21,26H2,1-3H3,(H,39,44)(H,40,43)(H,41,42)/t32-,35-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50097268 ((R)-N*1*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethy...) Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccc(cc1)-c1ccccc1)CC(=O)NO)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C38H43N3O4/c1-38(2,3)35(37(44)39-34(30-17-9-5-10-18-30)31-19-11-6-12-20-31)40-36(43)32(26-33(42)41-45)21-13-14-27-22-24-29(25-23-27)28-15-7-4-8-16-28/h4-12,15-20,22-25,32,34-35,45H,13-14,21,26H2,1-3H3,(H,39,44)(H,40,43)(H,41,42)/t32-,35-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Concentration required to inhibit the catalytic domain Matrix metalloprotease-2 using Nagase fluorogenic as a substrate.				Bioorg Med Chem Lett 11: 571-4 (2001) BindingDB Entry DOI: 10.7270/Q22B8X9X
					More data for this Ligand-Target Pair