BDBM50097819 4-[(E)-3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid::CHEMBL165843
SMILES: CC1(C)CCC(C)(C)c2cc(C\C=C\c3ccc(cc3)C(O)=O)ccc12
InChI Key: InChIKey=PGOLJNQIMGAPBE-AATRIKPKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Retinoic acid receptor gamma (Homo sapiens (Human)) | BDBM50097819 (4-[(E)-3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc Curated by ChEMBL | Assay Description Binding affinity towards retinoic acid receptor gamma was determined using [3H]-ATRA (5 nM) as radioligand | Bioorg Med Chem Lett 11: 765-8 (2001) BindingDB Entry DOI: 10.7270/Q2348JN3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50097819 (4-[(E)-3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc Curated by ChEMBL | Assay Description Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligand | Bioorg Med Chem Lett 11: 765-8 (2001) BindingDB Entry DOI: 10.7270/Q2348JN3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50097819 (4-[(E)-3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
Allergan Inc Curated by ChEMBL | Assay Description Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor alpha | Bioorg Med Chem Lett 11: 765-8 (2001) BindingDB Entry DOI: 10.7270/Q2348JN3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor beta (Homo sapiens (Human)) | BDBM50097819 (4-[(E)-3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Allergan Inc Curated by ChEMBL | Assay Description Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor beta | Bioorg Med Chem Lett 11: 765-8 (2001) BindingDB Entry DOI: 10.7270/Q2348JN3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor gamma (Homo sapiens (Human)) | BDBM50097819 (4-[(E)-3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Allergan Inc Curated by ChEMBL | Assay Description Binding affinity towards retinoic acid receptor beta was determined using [3H]-ATRA (5 nM) as radioligand | Bioorg Med Chem Lett 11: 765-8 (2001) BindingDB Entry DOI: 10.7270/Q2348JN3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor beta (Homo sapiens (Human)) | BDBM50097819 (4-[(E)-3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc Curated by ChEMBL | Assay Description Binding affinity towards retinoic acid receptor beta was determined using [3H]-ATRA (5 nM) as radioligand | Bioorg Med Chem Lett 11: 765-8 (2001) BindingDB Entry DOI: 10.7270/Q2348JN3 | |||||||||||
More data for this Ligand-Target Pair |