null
SMILES: FC(F)(F)CNC(=O)C1(CCCCn2cnc3c(NC(=O)c4ccccc4-c4ccc(cc4)C(F)(F)F)cccc23)c2ccccc2-c2ccccc12
InChI Key: InChIKey=WFOHFXRVZBRLFW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human)) | BDBM50098325 (9-(4-{4-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of human Microsomal Triglyceride Transfer Protein (triglyceride transfer assay) | J Med Chem 44: 851-6 (2001) BindingDB Entry DOI: 10.7270/Q2N015S8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human)) | BDBM50098325 (9-(4-{4-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay | J Med Chem 44: 851-6 (2001) BindingDB Entry DOI: 10.7270/Q2N015S8 | |||||||||||
More data for this Ligand-Target Pair |