BDBM50098712 CHEMBL3593336

SMILES: CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(Cl)c1)\C#N

InChI Key: InChIKey=AJULDISTXQVFCV-FYJGNVAPSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50098712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098712 (CHEMBL3593336) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 4 (Mus musculus)	BDBM50098712 (CHEMBL3593336) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair