BDBM50099322 3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-5-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione::A-119637::CHEMBL268758
SMILES: COc1ccccc1N1CCN(CCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1
InChI Key: InChIKey=HLVQBOYEHQRWHG-UHFFFAOYSA-N
Data: 13 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Alpha-1D adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.213 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity towards rat Alpha-1D adrenergic receptor | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.252 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human Alpha-1D adrenergic receptor | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cerebral cortex alpha adrenergic receptor (CALF) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.274 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity towards bovine Alpha-1A adrenergic receptor | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro functional activity at Alpha-1A adrenergic receptor in rat vas deferens | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active | Bioorg Med Chem Lett 15: 657-64 (2005) Article DOI: 10.1016/j.bmcl.2004.11.032 BindingDB Entry DOI: 10.7270/Q2SN08GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity for human Alpha-1A adrenergic receptor | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic alpha1B (Homo sapiens (Human)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human Alpha-1B adrenergic receptor | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Ancillary Binding affinity towards rat Dopamine receptor D2 | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (NEONATAL RAT) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Ancillary Binding affinity towards rat alpha-2B receptor | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Ancillary Binding affinity to cloned human Alpha-2C adrenergic receptor | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptor | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 1 (5-HT1) receptor (RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | PDB MMDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro functional activity at Alpha-1B adrenergic receptor in rat spleen | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (RAT) | BDBM50099322 (3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 6.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Ancillary Binding affinity to rat Dopamine receptor D1 | Bioorg Med Chem Lett 11: 1119-21 (2001) BindingDB Entry DOI: 10.7270/Q20V8DBQ | |||||||||||
More data for this Ligand-Target Pair |