BindingDB PrimarySearch

BDBM50099857 ACETOHYDROXAMIC ACID (AHA)::AHA::Acethydroxamsaeure::Acethydroxamsaure::Acetic acid, oxime::Acetylhydroxamic acid::Cetohyroxamic acid::Lithostat::Methylhydroxamic acid::N-Acetyl hydroxyacetamide::N-Acetylhydroxylamine::N-Hydroxyacetamide::acetohydroxamic acid

SMILES: CC(=O)NO

InChI Key: InChIKey=RRUDCFGSUDOHDG-UHFFFAOYSA-N

Data: 1 KI 38 IC50 2 Kd

PDB links: 29 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 50099857
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	9.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wroc?aw University of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant Helicobacter pylori urease expressed in Escherichia coli rosetta DE3 after 120 mins by Berthelot colorimetric analysis				J Med Chem 59: 8125-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00986
Wroc?aw University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit alpha (Escherichia coli)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Karachi Curated by ChEMBL					Assay Description Inhibition of bacterial urease using urea as substrate preincubated for 15 mins followed by substrate addition by ELISA				Bioorg Med Chem 27: 1009-1022 (2019) Article DOI: 10.1016/j.bmc.2019.01.043
University of Karachi Curated by ChEMBL					More data for this Ligand-Target Pair
Urease (Helicobacter pylori ATCC43504)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	4.25E+4	n/a	n/a	n/a	n/a	7.4	4
Wuhan Textile University					Assay Description Briefly, 50 mL broth cultures (2.0 × 10^8 CFU/mL) were centrifuged (5000g, 4°C)to collect the bacteria, and after washing twice with phosph...				J Enzyme Inhib Med Chem 27: 528-32 (2012) Article DOI: 10.3109/14756366.2011.599065 BindingDB Entry DOI: 10.7270/Q2445KC3
Wuhan Textile University					More data for this Ligand-Target Pair				3D Structure (crystal)
Peptide Deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Curated by ChEMBL					Assay Description Inhibition of Peptidyl deformylase (PDF)				Bioorg Med Chem Lett 11: 1355-8 (2001) BindingDB Entry DOI: 10.7270/Q2D50M7N
Pharmacia Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	n/a	1.70E+7	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.				J Med Chem 45: 5628-39 (2002) BindingDB Entry DOI: 10.7270/Q20C4V3M
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human CA2				Bioorg Med Chem Lett 16: 4316-20 (2006) Article DOI: 10.1016/j.bmcl.2006.05.068 BindingDB Entry DOI: 10.7270/Q2HX1C9J
Università degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Urease (Canavalia ensiformis (Jack bean) (Horse bean))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	1.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of jack bean urease				J Nat Prod 69: 1800-2 (2006) Article DOI: 10.1021/np060242y BindingDB Entry DOI: 10.7270/Q2348K4S
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	6.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HDAC1				Bioorg Med Chem Lett 17: 4562-7 (2007) Article DOI: 10.1016/j.bmcl.2007.05.091 BindingDB Entry DOI: 10.7270/Q2CC10C4
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Urease (Canavalia ensiformis (Jack bean) (Horse bean))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universiti Teknologi MARA Puncak Alam Campus Curated by ChEMBL					Assay Description Inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by Weatherburn assay				Bioorg Med Chem Lett 25: 3285-9 (2015) BindingDB Entry DOI: 10.7270/Q2GT5PZZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	6.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human HDAC1 expressed in domain of SMRT				Bioorg Med Chem Lett 17: 4619-24 (2007) Article DOI: 10.1016/j.bmcl.2007.05.080 BindingDB Entry DOI: 10.7270/Q2WH2PPV
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Antrax lethal toxin (Bacillus anthracis)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.14E+7	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of recombinant anthrax lethal factor after 30 mins by fluorescence assay				J Med Chem 54: 591-602 (2011) Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.50E+7	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2 after 30 mins				J Med Chem 54: 591-602 (2011) Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	1.70E+7	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Dissociation constant for Matrix Metalloprotease-3 (MMP-3)				J Med Chem 47: 3463-82 (2004) Article DOI: 10.1021/jm040031v BindingDB Entry DOI: 10.7270/Q2NC61ZJ
Sunesis Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Urease (Canavalia ensiformis (Jack bean) (Horse bean))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	4.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
Quaid-i-Azam University Curated by ChEMBL					Assay Description Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol method				Eur J Med Chem 70: 487-96 (2013) Article DOI: 10.1016/j.ejmech.2013.10.012 BindingDB Entry DOI: 10.7270/Q2W097DC
Quaid-i-Azam University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Succinyl-diaminopimelate desuccinylase (Haemophilus influenzae)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Loyola University Curated by ChEMBL					Assay Description Inhibition of Haemophilus influenzae recombinant DapE				Bioorg Med Chem Lett 19: 6350-2 (2009) Article DOI: 10.1016/j.bmcl.2009.09.077 BindingDB Entry DOI: 10.7270/Q2833T06
Loyola University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2				J Med Chem 54: 2529-91 (2011) Article DOI: 10.1021/jm1013693 BindingDB Entry DOI: 10.7270/Q24M95PH
					More data for this Ligand-Target Pair				3D Structure (docked)
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.72E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of urease in Helicobacter pylori ATCC 43504 assessed as reduction in ammonia production preincubated for 1.5 hrs by indophenol method				Eur J Med Chem 156: 126-136 (2018) Article DOI: 10.1016/j.ejmech.2018.06.065 BindingDB Entry DOI: 10.7270/Q2N87DBC
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production preincubated for 1.5 hrs under cell free condition by...				Eur J Med Chem 156: 126-136 (2018) Article DOI: 10.1016/j.ejmech.2018.06.065 BindingDB Entry DOI: 10.7270/Q2N87DBC
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of urease in Helicobacter pylori ATCC 43504 assessed as reduction in ammonia production using urea as substrate preincubated for 1.5 hrs b...				Bioorg Med Chem 26: 4145-4152 (2018) Article DOI: 10.1016/j.bmc.2018.07.003 BindingDB Entry DOI: 10.7270/Q2N87DFQ
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production using urea as substrate preincubated for 1.5 hrs unde...				Bioorg Med Chem 26: 4145-4152 (2018) Article DOI: 10.1016/j.bmc.2018.07.003 BindingDB Entry DOI: 10.7270/Q2N87DFQ
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of urease in Helicobacter pylori ATCC 43504 assessed as ammonia production incubated for 1.5 hrs prior to testing by indophenol method				Bioorg Med Chem 23: 4508-4513 (2015) Article DOI: 10.1016/j.bmc.2015.06.014 BindingDB Entry DOI: 10.7270/Q2T43X33
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori urease assessed as ammonia production preincubated for 1.5 hrs by indophenol method				Bioorg Med Chem 23: 4860-4865 (2015) Article DOI: 10.1016/j.bmc.2015.05.026 BindingDB Entry DOI: 10.7270/Q2HQ42XZ
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	1.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori urease after 50 mins by indophenol method				Bioorg Med Chem Lett 28: 3182-3186 (2018) Article DOI: 10.1016/j.bmcl.2018.08.025 BindingDB Entry DOI: 10.7270/Q2PN9894
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.84E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of urease isolated from Helicobacter pylori ATCC 43504 assessed as ammonia production incubated for 1.5 hrs prior to testing by indophenol...				Bioorg Med Chem 23: 4508-4513 (2015) Article DOI: 10.1016/j.bmc.2015.06.014 BindingDB Entry DOI: 10.7270/Q2T43X33
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease in presence of 0.4 mM dithiothreitol after 3 hrs pre-incubation				Bioorg Med Chem 15: 3703-10 (2007) Article DOI: 10.1016/j.bmc.2007.03.045 BindingDB Entry DOI: 10.7270/Q2P55R84
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease after 3 hrs pre-incubation				Bioorg Med Chem 15: 3703-10 (2007) Article DOI: 10.1016/j.bmc.2007.03.045 BindingDB Entry DOI: 10.7270/Q2P55R84
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease in presence of 0.4 mM 2-mercaptoethanol after 3 hrs pre-incubation				Bioorg Med Chem 15: 3703-10 (2007) Article DOI: 10.1016/j.bmc.2007.03.045 BindingDB Entry DOI: 10.7270/Q2P55R84
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease assessed as ammonia production by indophenol method				Eur J Med Chem 44: 2246-51 (2009) Article DOI: 10.1016/j.ejmech.2008.06.001 BindingDB Entry DOI: 10.7270/Q2F192JD
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of urease in Helicobacter pylori ATCC 43504 intact cell assessed as ammonia production preincubated for 1.5 hrs by indophenol-based method				Eur J Med Chem 68: 212-21 (2013) Article DOI: 10.1016/j.ejmech.2013.07.047 BindingDB Entry DOI: 10.7270/Q28G8PNR
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of urease extracted from Helicobacter pylori ATCC 43504 assessed as ammonia production preincubated for 1.5 hrs by indophenol-based method				Eur J Med Chem 68: 212-21 (2013) Article DOI: 10.1016/j.ejmech.2013.07.047 BindingDB Entry DOI: 10.7270/Q28G8PNR
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
Liaoning Normal University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori urease assessed as ammonia production preincubated for 3 hrs measured by indophenol method				Bioorg Med Chem 20: 4889-94 (2012) Article DOI: 10.1016/j.bmc.2012.07.002 BindingDB Entry DOI: 10.7270/Q2BZ68X2
Liaoning Normal University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease-mediated ammonia production preincubated for 1.5 hrs by indophenol method				Eur J Med Chem 63: 685-95 (2013) Article DOI: 10.1016/j.ejmech.2013.03.016 BindingDB Entry DOI: 10.7270/Q2D79FB1
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease assessed as ammonia production after 3 hrs by indophenol method				Bioorg Med Chem 17: 7531-6 (2009) Article DOI: 10.1016/j.bmc.2009.09.018 BindingDB Entry DOI: 10.7270/Q270847M
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of urease in intact Helicobacter pylori ATCC 43504 assessed as reduction in ammonia production by indophenol based Berthelot color reactio...				Eur J Med Chem 45: 5064-70 (2010) Article DOI: 10.1016/j.ejmech.2010.08.015 BindingDB Entry DOI: 10.7270/Q2R78J2D
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of cell free Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production by indophenol based Berthelot color reactio...				Eur J Med Chem 45: 5064-70 (2010) Article DOI: 10.1016/j.ejmech.2010.08.015 BindingDB Entry DOI: 10.7270/Q2R78J2D
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori urease using urea as substrate assessed as ammonia production after 50 mins by indophenol method				Bioorg Med Chem 24: 4519-4527 (2016) Article DOI: 10.1016/j.bmc.2016.07.052
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	9.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wroc?aw University of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant Helicobacter pylori urease expressed in Escherichia coli rosetta DE3 using urea as substrate assessed as transformed cell u...				J Med Chem 59: 8125-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00986
Wroc?aw University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.54E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wroc?aw University of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant Helicobacter pylori urease expressed in Escherichia coli rosetta DE3 using urea as substrate assessed as transformed cell u...				J Med Chem 59: 8125-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00986
Wroc?aw University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.56E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wroc?aw University of Technology Curated by ChEMBL					Assay Description Inhibition of urease in Helicobacter pylori J99 in Brucella broth using urea as substrate preincubated for 2 hrs followed by substrate addition measu...				J Med Chem 59: 8125-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00986
Wroc?aw University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Urease (Canavalia ensiformis (Jack bean))	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	4.32E+4	n/a	n/a	n/a	n/a	8.2	37
Quaid-I-Azam University, Islamabad, Pakistan.					Assay Description The assay mixture contained 40 µL of buffer (0.01 M LiCl2, 1 mM EDTA, 0.01M K2HPO4, pH 8.2) containing 100 mM urea, 10 µL of enzyme (5U/mL)...				Bioorg Chem 52: 1-7 (2014) Article DOI: 10.1016/j.bioorg.2013.10.001 BindingDB Entry DOI: 10.7270/Q2X34W43
Quaid-I-Azam University, Islamabad, Pakistan.					More data for this Ligand-Target Pair				3D Structure (crystal)
Urease (Helicobacter pylori)	BDBM50099857 (ACETOHYDROXAMIC ACID (AHA) \| AHA \| Acethydroxamsae...) Show SMILES CC(=O)NO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Minia University					Assay Description The assay mixture, containing 50 μl (2 mg/ml) of enzyme and 100 μl of different concentration of the tested agents, was added to 850 μ...				Bioorg Chem 70: 1-11 (2017) Article DOI: 10.1016/j.bioorg.2016.11.002 BindingDB Entry DOI: 10.7270/Q2PZ57NS
Minia University					More data for this Ligand-Target Pair				3D Structure (crystal)