BDBM50099960 (1-Benzyl-1H-indazol-5-yl)-(6,7-dimethoxy-quinazolin-4-yl)-amine::CHEMBL416031

SMILES: COc1cc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c2cc1OC

InChI Key: InChIKey=YILRBOLKDDWRKU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50099960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor protein-tyrosine kinase erbB-2 (Rattus norvegicus)	BDBM50099960 ((1-Benzyl-1H-indazol-5-yl)-(6,7-dimethoxy-quinazol...) Show SMILES COc1cc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c2cc1OC Show InChI InChI=1S/C24H21N5O2/c1-30-22-11-19-20(12-23(22)31-2)25-15-26-24(19)28-18-8-9-21-17(10-18)13-27-29(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Research Biomet. Glaxo Wellcome Medicines Research Centre Curated by ChEMBL					Assay Description Inhibition of rat Receptor protein-tyrosine kinase erbB2				Bioorg Med Chem Lett 11: 1401-5 (2001) BindingDB Entry DOI: 10.7270/Q2W37VKB
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50099960 ((1-Benzyl-1H-indazol-5-yl)-(6,7-dimethoxy-quinazol...) Show SMILES COc1cc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c2cc1OC Show InChI InChI=1S/C24H21N5O2/c1-30-22-11-19-20(12-23(22)31-2)25-15-26-24(19)28-18-8-9-21-17(10-18)13-27-29(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Research Biomet. Glaxo Wellcome Medicines Research Centre Curated by ChEMBL					Assay Description Inhibition of c-erbB-2 overexpressing HB4a cell proliferation				Bioorg Med Chem Lett 11: 1401-5 (2001) BindingDB Entry DOI: 10.7270/Q2W37VKB
					More data for this Ligand-Target Pair