BDBM50100300 2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL22659
SMILES: Clc1ccc(Sc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1
InChI Key: InChIKey=JRTOBKVVIBBEQD-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50100300 (2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran... | Bioorg Med Chem Lett 11: 1257-60 (2001) BindingDB Entry DOI: 10.7270/Q2FX78RS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50100300 (2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran... | Bioorg Med Chem Lett 11: 1257-60 (2001) BindingDB Entry DOI: 10.7270/Q2FX78RS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50100300 (2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran... | Bioorg Med Chem Lett 11: 1257-60 (2001) BindingDB Entry DOI: 10.7270/Q2FX78RS | |||||||||||
More data for this Ligand-Target Pair |