BDBM50100519 CHEMBL3327067::US10377744, Compound No. 2391
SMILES: CC[C@H](C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(cc1)C(F)(F)F
InChI Key: InChIKey=GYIFHGGYNPKLFC-LBPRGKRZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM50100519 (CHEMBL3327067 | US10377744, Compound No. 2391) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Davis Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay | J Med Chem 57: 7016-30 (2014) Article DOI: 10.1021/jm500694p BindingDB Entry DOI: 10.7270/Q2FJ2JJQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM50100519 (CHEMBL3327067 | US10377744, Compound No. 2391) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eicosis, LLC US Patent | Assay Description FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-... | US Patent US10377744 (2019) BindingDB Entry DOI: 10.7270/Q2N3009K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Soluble epoxide hydrolase (sEH) (Mus musculus (Mouse)) | BDBM50100519 (CHEMBL3327067 | US10377744, Compound No. 2391) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 17.8 | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of California US Patent | Assay Description Trans-diphenylpropene oxide is used in a radiometric competitive assay. | US Patent US9296693 (2016) BindingDB Entry DOI: 10.7270/Q2TX3D7M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Soluble epoxide hydrolase (sEH) (Mus musculus (Mouse)) | BDBM50100519 (CHEMBL3327067 | US10377744, Compound No. 2391) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of California US Patent | Assay Description fluoresence competitive assay. | US Patent US9296693 (2016) BindingDB Entry DOI: 10.7270/Q2TX3D7M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epoxide hydrolase 2 (Rattus norvegicus) | BDBM50100519 (CHEMBL3327067 | US10377744, Compound No. 2391) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Davis Curated by ChEMBL | Assay Description Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assay | J Med Chem 57: 7016-30 (2014) Article DOI: 10.1021/jm500694p BindingDB Entry DOI: 10.7270/Q2FJ2JJQ | |||||||||||
More data for this Ligand-Target Pair |