BDBM50100674 CHEMBL541818::methyl 2-(4-aminophenyl)-4-(3,5-dimethoxy-4-methylphenyl)-1-oxo-7-(2-pyridylmethoxy)-1,2-dihydro-3-isoquinolinecarboxylate.dihydrochloride
SMILES: COC(=O)c1c(-c2cc(OC)c(C)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1
InChI Key: InChIKey=IEXOQDWHLPVRNW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50100674 (CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Relaxant effect on isolated rabbit corpus cavernosum | J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris) | BDBM50100674 (CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) | J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 2A (Bos taurus) | BDBM50100674 (CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of bovine adrenal gland Phosphodiesterase 2 (PDE2) | J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 4 (Homo sapiens (Human)) | BDBM50100674 (CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of canine lung Phosphodiesterase 4 (PDE4) | J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50100674 (CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against canine heart Phosphodiesterase 3 (PDE3) | J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 1 (Rattus norvegicus) | BDBM50100674 (CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) | J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5 | |||||||||||
More data for this Ligand-Target Pair |