null

SMILES: COc1cc(cc(OC)c1OC)-c1c(C(=O)N(C)C)n(-c2ccc(N)cc2)c(=O)c2cc(OCc3ccccn3)ccc12

InChI Key: InChIKey=GXPNMEZJOKAJRL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50100675   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50100675 (3N,3N-dimethyl-2-(4-aminophenyl)-1-oxo-7-(2-pyridy...) Show SMILES COc1cc(cc(OC)c1OC)-c1c(C(=O)N(C)C)n(-c2ccc(N)cc2)c(=O)c2cc(OCc3ccccn3)ccc12 Show InChI InChI=1S/C33H32N4O6/c1-36(2)33(39)30-29(20-16-27(40-3)31(42-5)28(17-20)41-4)25-14-13-24(43-19-22-8-6-7-15-35-22)18-26(25)32(38)37(30)23-11-9-21(34)10-12-23/h6-18H,19,34H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5)				J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase (Rattus norvegicus)	BDBM50100675 (3N,3N-dimethyl-2-(4-aminophenyl)-1-oxo-7-(2-pyridy...) Show SMILES COc1cc(cc(OC)c1OC)-c1c(C(=O)N(C)C)n(-c2ccc(N)cc2)c(=O)c2cc(OCc3ccccn3)ccc12 Show InChI InChI=1S/C33H32N4O6/c1-36(2)33(39)30-29(20-16-27(40-3)31(42-5)28(17-20)41-4)25-14-13-24(43-19-22-8-6-7-15-35-22)18-26(25)32(38)37(30)23-11-9-21(34)10-12-23/h6-18H,19,34H2,1-5H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against rat heart Phosphodiesterase 1(PDE1)				J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50100675 (3N,3N-dimethyl-2-(4-aminophenyl)-1-oxo-7-(2-pyridy...) Show SMILES COc1cc(cc(OC)c1OC)-c1c(C(=O)N(C)C)n(-c2ccc(N)cc2)c(=O)c2cc(OCc3ccccn3)ccc12 Show InChI InChI=1S/C33H32N4O6/c1-36(2)33(39)30-29(20-16-27(40-3)31(42-5)28(17-20)41-4)25-14-13-24(43-19-22-8-6-7-15-35-22)18-26(25)32(38)37(30)23-11-9-21(34)10-12-23/h6-18H,19,34H2,1-5H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against canine heart Phosphodiesterase 3 (PDE3)				J Med Chem 44: 2204-18 (2001) BindingDB Entry DOI: 10.7270/Q2QR4XT5
					More data for this Ligand-Target Pair