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BDBM50101676 CHEMBL3394921

SMILES: COc1cc(C\C=N\NC(=O)c2ccc(NC(=O)c3ccccc3)cc2)cc(Br)c1O

InChI Key: InChIKey=HXGGEEUUJXMVEQ-BRJLIKDPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50101676   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone chaperone ASF1A


(Homo sapiens (Human))		BDBM50101676
PNG
(CHEMBL3394921)
Show SMILES COc1cc(C\C=N\NC(=O)c2ccc(NC(=O)c3ccccc3)cc2)cc(Br)c1O
Show InChI InChI=1S/C23H20BrN3O4/c1-31-20-14-15(13-19(24)21(20)28)11-12-25-27-23(30)17-7-9-18(10-8-17)26-22(29)16-5-3-2-4-6-16/h2-10,12-14,28H,11H2,1H3,(H,26,29)(H,27,30)/b25-12+
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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Colorado State University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human Asf1a binding with H3/H4 assessed as fluorescence intensity after 30 mins by ALPHA assay

Bioorg Med Chem Lett 25: 963-8 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.067
BindingDB Entry DOI: 10.7270/Q2VM4F0G
More data for this
Ligand-Target Pair