BindingDB PrimarySearch

BDBM50101866 2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-carboxamidine::CHEMBL52427

SMILES: Cc1cc(-c2cc3cc(ccc3[nH]2)C(N)=N)c(O)c(c1)-c1ccccc1

InChI Key: InChIKey=ALBWLRSLXFJFTE-UHFFFAOYSA-N

Data: 11 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50101866
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory concentration against Human Serine Protease Urokinase Plasminogen Activator				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
Axys Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inihibtion of Human Serine Protease tissue type Plasminogen Activator				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
Axys Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against urokinase-type plasminogen activator (microPa) in human plasma				Bioorg Med Chem Lett 11: 1797-800 (2001) BindingDB Entry DOI: 10.7270/Q20K27TW
Axys Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity against Human Serine Protease Trypsin				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
Axys Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity against human coagulation factor X				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
Axys Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of Human Serine Protease Plasmin				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
Axys Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	640	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Coagulation factor X in human plasma				Bioorg Med Chem Lett 11: 1797-800 (2001) BindingDB Entry DOI: 10.7270/Q20K27TW
Axys Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity against Human Serine Protease Thrombin				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
Axys Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against plasmin in human plasma				Bioorg Med Chem Lett 11: 1797-800 (2001) BindingDB Entry DOI: 10.7270/Q20K27TW
Axys Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against trypsin in human plasma				Bioorg Med Chem Lett 11: 1797-800 (2001) BindingDB Entry DOI: 10.7270/Q20K27TW
Axys Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50101866 (2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against thrombin(fIIa) in human plasma				Bioorg Med Chem Lett 11: 1797-800 (2001) BindingDB Entry DOI: 10.7270/Q20K27TW
Axys Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair